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c/sideeffects·posted 10 months ago by u/blunt_coldbox_2024

small win: nausea stopped being a problem at week 35

Resolved Long Haul ×8 Sourced ×3

small win: nausea stopped being a problem at week 35, logged the same way every week so the comparison is at least internally fair.

Bought four different things to fix my sulphur burps. What actually worked was eating half as fast.

injection-site soreness for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

2,093 up / 378 down85% upvoted65 commentsid dgwsj012 Sep 2025

65 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/mass_spec_maggieMS129 points·10 months ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/britt_abubakar87 points·10 months ago

eating slower does more than most of the supplements people recommend

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u/priya_weiss58 points·10 months ago

the food noise going quiet is the effect people came for, and sulphur burps are the toll for the first fortnight

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u/chidi_abubakar31 points·10 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/slow_logbook_ftw25 points·10 months ago

write down when it starts and stops, the pattern is the useful part

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u/emil_barros61 points·10 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/ferritin_low-14 points·10 months ago

What is intake actually looking like — fibre and water especially?

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u/aa_analysis_andy1 point·10 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 46 probably does not, and that is worth saying to a clinician rather than to us.

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u/chidi_abubakar97 points·10 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/janoshik_junkieindependent tester52 points·10 months ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/aa_analysis_andy75 points·10 months ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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u/sofia_wikstrom60 points·10 months ago

early fullness on day two and gone by day four is the standard shape

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u/blunt_coldbox_2024OP32 points·10 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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[deleted]29 points·10 months ago

[deleted]

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u/aa_analysis_andy34 points·10 months ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/wrong_network_w63 points·10 months ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/britt_abubakar58 points·10 months ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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u/ayesha_radich38 points·10 months ago·edited

the first fortnight after a step is the worst of it, then it settles

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u/chidi_abubakar45 points·10 months ago

Mine settled at week 62 and has not come back since, across two more steps.

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u/quiet_moderatormod56 points·10 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/ferran_krastev22 points·10 months ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/janoshik_junkieindependent tester39 points·10 months ago

Held the dose for an extra six weeks instead of stepping. The reflux settled and I lost the same amount anyway.

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u/halima_mbeki18 points·10 months ago

Yes. Holding the dose is a real option and it does not mean you have failed at anything.

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u/diego_sorensen9 points·10 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/blunt_coldbox_2024OP4 points·10 months ago

Has anything else changed in the same window?

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u/chidi_demir3 points·10 months ago

fibre and water before you buy anything to fix it

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u/cesar_oyelaran6 points·10 months ago

the fatigue that arrives at week 89 out of nowhere is usually something else

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u/fatima_asante2 points·10 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/constipation_clubside effects1 point·10 months ago

fatigue plus low intake is usually just low intake

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u/blank_injection4 points·10 months ago

Is it every week or did it start at a particular dose?

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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