1.2k
[Failure] gel pack arrived liquid and warm in July. photos at unboxing.
July shipment, long lane, small reseller I bought from once and will not name because the packing is not the manufacturer's. Gel pack fully liquid and noticeably warm…
Cold Chain
c/coldchain · created 19 Oct 2023
Data loggers, excursions, packaging failures. Peptides survive more than you think.
Hot
-18
[Data] logger trace: 6 days transit, 41 hours above 8°C, powder was fine
Dropped an £18 USB logger in the box. Full trace summarised: Segment Hours Max Note Origin to airport 9 9.1°C gel pack still solid In transit 26 21.4°C pack fully…
614
posted 4 days ago by u/first_pen_fear
reconstituted vial left out for five hours — bin it or notTook it out to draw, got distracted by a phone call, found it on the counter five hours later. Room temperature, maybe 21°C, out of direct light. It is reconstituted,…
707
posted 5 days ago by u/cesar_teixeira
[Data] logger trace: 6 days transit, 41 hours above 8°C, powder was finePosting this as a discussion rather than a claim: logger trace: 6 days transit, 41 hours above 8°C, powder was fine. Numbers, in the order they matter: 6 days and 41…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards470
posted 5 days ago by u/kian_ekstrom
[Failure] gel pack arrived liquid and warm. photos at unboxing.Check-in as promised in the title: gel pack arrived liquid and warm. photos at unboxing. Seasonality, which the source-page lane tables show clearly once you look for…
976
posted 7 days ago by u/analog_alphabet
[Explainer] lyophilised powder is far more forgiving than you thinklyophilised powder is far more forgiving than you think. Two minutes of reading now saves an argument later. Split an order across two months deliberately to compare…
533
posted 8 days ago by u/certified_reference
£18 USB logger settled a three-week argument in thirty seconds£18 USB logger settled a three-week argument in thirty seconds. Change my mind, genuinely — I have no stake in being right about this. The numbers the title promised,…
635
posted 10 days ago by u/marit_laurent
[PSA] never the fridge door. the door is the warmest wobbliest shelf you ownnever the fridge door. the door is the warmest wobbliest shelf you own. That is the post. The justification is underneath. Gel pack fully liquid on arrival, powder…
894
posted 13 days ago by u/zeynep_ndiaye
[Data] my fridge is 2.1°C at the back and 7.8°C in the door. same fridge.Thinking out loud about this: my fridge is 2.1°C at the back and 7.8°C in the door. same fridge. Regional stock changes the question rather than answering it: shorter…
193
posted 15 days ago by u/ireland_drugs_pay
[Question] reconstituted vial left out for five hours — bin it or notQuestion in the title, detail here: reconstituted vial left out for five hours — bin it or not. You cannot infer potency from a temperature record. The record tells you…
243
posted 17 days ago by u/cesar_teixeira
[Failure] vendor packed a cold box with no thermal mass. just foam and hope.vendor packed a cold box with no thermal mass. just foam and hope. This is a description of what happened to me and not a plan for anybody else. A transit temperature…
1.2k
posted 21 days ago by u/ines_lindqvist
freezing reconstituted product: why the answer is nofreezing reconstituted product: why the answer is no. Not a hot take, just something I have not seen said plainly here. Once in solution, the relevant risks are…
125
posted 23 days ago by u/analog_alphabet
[Explainer] excursion tables, and why "it got warm" is not a data pointexcursion tables, and why "it got warm" is not a data point. It comes up every few weeks and the answer has not changed. Kept a vial at room temperature for eleven days…
1.3k
posted 26 days ago by u/kian_ekstrom
[Data] 41 lanes, 900 data points, transit temperature by carrier41 lanes, 900 data points, transit temperature by carrier. It is the sort of thing everyone half-believes and nobody writes down. Wrote the reconstitution date on the…
327
posted 1 months ago by u/andres_restrepo
light exposure matters more for some compounds than others and nobody tabulates itPosting this as a discussion rather than a claim: light exposure matters more for some compounds than others and nobody tabulates it. A transit temperature logger…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net822
posted 1 months ago by u/marit_laurent
someone explain lyophilised to me like I have not read a paper in yearssomeone explain lyophilised to me like I have not read a paper in years. If this has been answered properly somewhere, link me and I will delete. Seasonality, which the…
1k
posted 1 months ago by u/coldchain_karen
does ice pack actually matter or is it forum lore at this pointSlightly embarrassed to be asking this, but: does ice pack actually matter or is it forum lore at this point. A stability statement is only meaningful with its…
64
posted 1 months ago by u/adaeze_weiss
why does nobody talk about stabilitywhy does nobody talk about stability. I would rather ask a basic question now than get this wrong quietly for two months. Put a logger in three consecutive orders. Two…
1.5k
posted 1 months ago by u/sequence_checker
[Discussion] cold chain is doing more work than we give it credit forThe title is the argument: cold chain is doing more work than we give it credit for. Here is the rest of it. Lyophilisation removes the water that drives most…
74
posted 1 months ago by u/kian_solberg
[Question] how do you actually verify ice packhow do you actually verify ice pack. Searched first, found three threads that contradict each other, hence the post. Put a logger in three consecutive orders. Two never…
2.9k
the UK: excursion, and what it actually costs here
the UK: excursion, and what it actually costs here. Change my mind, genuinely — I have no stake in being right about this. Regional stock changes the question rather…
873
posted 2 months ago by u/tidy_vialdrawer_watch28
[Meta] proposal — a flair for data logger postsPutting this to the board: proposal — a flair for data logger posts. A transit temperature logger records a distribution, and time above a threshold matters as much as…
75
posted 2 months ago by u/anders_karlsen
[Discussion] stability is doing more work than we give it credit forThinking out loud about this: stability is doing more work than we give it credit for. Seasonality, which the source-page lane tables show clearly once you look for it.…
259
posted 2 months ago by u/nils_ferreira
someone explain stability to me like I have not read a paper in yearsSlightly embarrassed to be asking this, but: someone explain stability to me like I have not read a paper in years. Split an order across two months deliberately to…
931
posted 2 months ago by u/osman_brandt
[PSA] cold chain is not what most of this community thinks it iscold chain is not what most of this community thinks it is, written plainly and without the jargon that usually swallows this topic. What actually matters, in order,…