why does nobody talk about stability
why does nobody talk about stability. I would rather ask a basic question now than get this wrong quietly for two months.
Put a logger in three consecutive orders. Two never went above the range at all and the third spent four hours warm on a Friday. Cost me almost nothing to stop wondering.
Gel pack fully liquid on arrival, powder tested 98.1% against a claimed 97.5% afterwards. The pack had done its job for as long as it was designed to.
Gel packs are designed for a duty cycle. A liquid pack at the end of a longer-than-expected transit is a pack behaving as specified, not evidence of an excursion in the vial.
Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.
best — the order this archive was captured in
You cannot infer potency from a temperature record. The record tells you what happened to the box; only a test tells you what happened to the material.
Push back: you cannot infer degradation from a temperature excursion alone. That is what testing is for.
Correction: that stability figure covers the lyophilised powder, not the reconstituted solution. Different claim entirely.
ask what storage condition the stability statement was written against
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How many days in transit, and which month?
Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.
Retitled: the original asserted degradation the post does not evidence.
I would not freeze it in solution. That is a different failure mode and a worse one.
Lyophilisation removes the water that drives most degradation pathways. That is why the dry cake is comparatively robust and the reconstituted solution is not.
if you want to know, log it, otherwise you are guessing
Small fix — refrigerated, not frozen, once it is in solution.
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