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a pill with no food restrictions and no cold chain changes this entire site
Flairing this Speculation because that is what it is. Orforglipron is a small molecule, not a peptide. ATTAIN-1 and ACHIEVE-1 (both NEJM , 2025) reported the efficacy…
Orforglipron
c/orforglipron · created 25 Feb 2024
Oral non-peptide GLP-1. No food restrictions, no cold chain.
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posted 3 days ago by u/camila_vasquez
a pill with no food restrictions and no cold chain changes this entire sitea pill with no food restrictions and no cold chain changes this entire site, which sounds obvious until you try to state the evidence for it. It is a non-peptide…
533
posted 5 days ago by u/chidi_yilmaz
[Trial Data] ATTAIN-1 numbers, and why the % is not the headlineATTAIN-1 numbers, and why the % is not the headline. I have gone back and forth on this for months. Read both programme names carefully after mixing them up in a…
388
posted 6 days ago by u/canada_coverage
[Question] small molecule means purity testing is a different problem, rightTrying to get a straight answer on this: small molecule means purity testing is a different problem, right. What is actually known, and what is being assumed. Known: it…
Sigma-Aldrich — certified reference materials
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standards249
posted 8 days ago by u/deleted_my_history
[Speculation] what happens to the research-peptide supply chain if this landswhat happens to the research-peptide supply chain if this lands. I am not trying to be the "source?" guy. I would just like a source. Read both programme names…
305
posted 11 days ago by u/muscle_cramp_mo
[Paper] ACHIEVE-1 glycaemic data vs the injectablesACHIEVE-1 glycaemic data vs the injectables, which sounds obvious until you try to state the evidence for it. Spent an evening reading about small-molecule agonism at a…
322
posted 14 days ago by u/freya_marchand
[Discussion] non-peptide agonism is a genuinely different engineering problemnon-peptide agonism is a genuinely different engineering problem. I have gone back and forth on this for months. Read both programme names carefully after mixing them…
120
posted 18 days ago by u/dilara_weiss
reading non-peptide threads from 2024 and half of it aged badlyreading non-peptide threads from 2024 and half of it aged badly. Making the case below, and I expect to lose some of it in the comments. The no-timing-restriction thing…
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posted 22 days ago by u/taper_off_tabitha
why does nobody talk about ACHIEVEwhy does nobody talk about ACHIEVE — that is what I am asking, and I have already read the wiki twice. Analytically this is a small-molecule identity and purity…
336
posted 26 days ago by u/honest_syringe_maybe
[Results] 79 weeks, 21kg, and non-peptide was the hard part79 weeks, 21kg, and non-peptide was the hard part, and the part I actually want to talk about is at the bottom. Numbers, in the order they matter: 79 weeks and 21kg.…
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posted 1 months ago by u/neha_krastev
help me understand non-peptide, I have read the wiki twiceTrying to get a straight answer on this: help me understand non-peptide, I have read the wiki twice. Went looking for independent testing on this and found essentially…
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posted 1 months ago by u/chidi_yilmaz
anyone else notice oral GLP-1 kicking in around week 56Here it is: anyone else notice oral GLP-1 kicking in around week 56. One person, one log, no control group, so read it accordingly. Why "oral" is doing two completely…
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posted 1 months ago by u/flair_enthusiast
reading ATTAIN threads from 2024 and half of it aged badlyPosting this as a discussion rather than a claim: reading ATTAIN threads from 2024 and half of it aged badly. Milligram comparisons across molecule classes are…
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posted 2 months ago by u/lucia_bruun
three years of small molecule threads, summarised so you do not have to read themthree years of small molecule threads, summarised so you do not have to read them. Change my mind, genuinely — I have no stake in being right about this. Analytically…
32
posted 2 months ago by u/kavya_radich
switched from 10mg to 15mg and constipation got better, not worseSomething I keep coming back to: switched from 10mg to 15mg and constipation got better, not worse. Since the title puts numbers in the shop window: 10mg and 15mg.…
Janoshik Analytical — independent HPLC & mass spec
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredGL Biochem (Shanghai) Ltd. — the synthesis house
Est. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.net250
posted 2 months ago by u/dario_boateng
12 months in and orforglipron is still the thing I get wrongHere it is: 12 months in and orforglipron is still the thing I get wrong. One person, one log, no control group, so read it accordingly. The relevant figures are 12…
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posted 3 months ago by u/marit_sandvik
why does nobody talk about non-peptideGenuine question, and the title is the question: why does nobody talk about non-peptide. The no-timing-restriction thing is the part I would care about most in…
933
posted 3 months ago by u/honest_syringe_maybe
ACHIEVE: what the trials say vs what this community saysACHIEVE: what the trials say vs what this community says. Change my mind, genuinely — I have no stake in being right about this. Daily rather than weekly sounds trivial…
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posted 3 months ago by u/tidy_vialdrawer_watch28
[Results] 55 weeks on 5mg, full numbers, ask me anything boringReporting in. 55 weeks on 5mg, full numbers, ask me anything boring. The relevant figures are 55 weeks and 5mg, and they come from the same log I have kept the whole…
862
posted 3 months ago by u/first_hundred
week 66 check-in — 26kg down, fatigue manageable, one thing confusing meweek 66 check-in — 26kg down, fatigue manageable, one thing confusing me. Full detail below, and I have tried to keep the editorialising out of it. Pulling the figures…
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posted 4 months ago by u/salma_almeida
genuine question about oral GLP-1 that I am slightly embarrassed to askgenuine question about oral GLP-1 that I am slightly embarrassed to ask. I am not trying to be the "source?" guy. I would just like a source. Daily dosing gives a very…
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posted 4 months ago by u/rasmus_petrescu
am I the only one who found oral GLP-1 harder than the injectionsSlightly embarrassed to be asking this, but: am I the only one who found oral GLP-1 harder than the injections. The no-timing-restriction thing is the part I would care…
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posted 5 months ago by u/canada_coverage
8 months in and orforglipron is still the thing I get wrong8 months in and orforglipron is still the thing I get wrong, logged the same way every week so the comparison is at least internally fair. The relevant figures are 8…
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posted 5 months ago by u/emil_marchand
unpopular opinion: most of what gets said here about non-peptide is guessworkunpopular opinion: most of what gets said here about non-peptide is guesswork. Making the case below, and I expect to lose some of it in the comments. The…
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posted 5 months ago by u/incretin_ivy
[Meta] proposal — a flair for ACHIEVE postsproposal — a flair for ACHIEVE posts. Disagreement welcome, but bring a concrete alternative wording. Why "oral" is doing two completely different jobs in the sentences…