switched from 10mg to 15mg and constipation got better, not worse
Something I keep coming back to: switched from 10mg to 15mg and constipation got better, not worse.
Since the title puts numbers in the shop window: 10mg and 15mg.
Daily rather than weekly sounds trivial until you think about what a missed dose means in each case.
Went looking for independent testing on this and found essentially nothing, which was clarifying.
Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.
best — the order this archive was captured in
Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional tablet.
Oral semaglutide is a peptide co-formulated with an absorption enhancer and carries food and water timing requirements. A small molecule does not have that constraint, which is the practical distinction.
Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use.
no food and water restrictions is the practical difference people care about
no food and water restrictions is the practical difference people care about
Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.
Small fix — the two programme names got swapped upthread and it changes which population the figure came from.
Standing reminder: unapproved compound, research material is not for human use, and no schedules for other members.
Yes. Oral peptide with an absorption enhancer and oral small molecule are completely different propositions.
Correction: that is the oral peptide product, which is a different thing entirely. This one is a small molecule.
Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.
a non-peptide agonist does not degrade the way a peptide does
Compared milligram figures across two completely different molecule classes in a comment.
Adding the standing caveat — unapproved, and research material is not for human use.
Why "oral" is doing two completely different jobs in the sentences people write here.
Oral semaglutide is a peptide co-formulated with an absorption enhancer, which is why it comes with food and water timing requirements. This compound is a non-peptide small molecule that activates the same receptor, formulated as an ordinary tablet.
The practical consequences differ enormously: no timing constraints, a conventional manufacturing route, different stability behaviour, and a different analytical problem for anybody trying to verify identity or purity. Whenever a thread here compares the two, check which sense of "oral" each half is using.
Daily dosing, so what does the exposure profile look like across the day?