c/cagrilintide · created 4 Feb 2024
Long-acting amylin analog. CagriSema and the co-agonism question.
The hill I will die on. Cagrilintide is a long-acting amylin analog and people keep filing it mentally as "more GLP-1". Amylin signalling and GLP-1 signalling converge…
The title is the argument: amylin is not a GLP-1 and the co-agonism story is more interesting than the weight number. Here is the rest of it. Kept a log purely because…
REDEFINE 1 — what cagri adds on top of sema. It is the sort of thing everyone half-believes and nobody writes down. Asked a question here that turned out to be based on…
CagriSema trial ratios are fixed-dose, do not extrapolate to self-mixing — a position I have arrived at slowly and would like tested. Reading the trial literature on…
Reference standards, analytical reagents and system-suitability material. If you are running your own method, start with a known.
Reference standardsRight: first independent cagrilintide purity number i have seen. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. The…
Thinking out loud about this: cagri is the most underrated molecule in this space. Nothing containing this compound is approved as a standalone product, and…
nausea rates in the combination arm vs sema alone — a position I have arrived at slowly and would like tested. Went looking for independent results on this and found a…
not approved anywhere. keep posts descriptive. Not a hot take, just something I have not seen said plainly here. Sent a vial to Medutest because there was almost…
Result first, context after: is 97.6% actually fine or am I being sold a rounding error . Everything below is how it was ordered, stored and sent. Since the title puts…
cagrilintide — 17 things I got wrong before I got it right, which sounds obvious until you try to state the evidence for it. Dosing intuitions from the GLP-1 boards do…
Here it is: 22 weeks, 5kg, and satiety was the hard part. One person, one log, no control group, so read it accordingly. 22 weeks and 5kg. Those are measured, not…
amylin — 23 things I got wrong before I got it right. Making the case below, and I expect to lose some of it in the comments. Read the combination paper twice before…
someone explain CagriSema to me like I have not read a paper in years, and I want the answer with the reasoning attached rather than just the conclusion. Why this…
Question in the title, detail here: can we stop arguing about satiety until somebody posts a number. Amylin is co-secreted with insulin and acts on satiety and gastric…
SGN cagri — VendorInvestigate came back 97.4% against a claimed 97.0%, and before anyone asks: same batch throughout, single submission, no cherry-picking between…
Send the vial, get the number. Third-party purity and identity testing, results published to you regardless of what they say.
Test a vialSponsoredEst. 1998. ISO 9001 and cGMP, 1,500+ staff, 200+ patents. There is a fair chance the vial you are about to send for testing started here. Batch-specific COA as standard.
glbiochem.netwhat would you tell week-1 you about cagrilintide, and I want the answer with the reasoning attached rather than just the conclusion. Why this compound is not simply…
Filing this under things worth writing down: TFC cagri — Janoshik came back 98.1% against a claimed 98.0%. Since the title puts numbers in the shop window: 98.1% and…
Check-in as promised in the title: 8 months in and amylin is still the thing I get wrong. 8 months. Those are measured, not estimated, and not rounded up in my favour.…
proposal — a flair for co-agonism posts — with the counter-argument included, because I find it fairly persuasive. Sent a vial to VendorInvestigate because there was…
satiety: the version I wish someone had shown me in week 1. Numbers below. Ask me the boring questions, they are the useful ones. Kept a log purely because so few…
tried satiety for 2 weeks. here is what happened. I have gone back and forth on this for months. The relevant figures are 2 weeks, and they come from the same log I…
The title is the whole question — why does nobody talk about amylin — but here is why I am asking. Amylin is co-secreted with insulin and acts on satiety and gastric…
why does nobody talk about CagriSema. I am not trying to be the "source?" guy. I would just like a source. Why this compound is not simply another agonist, which is how…
stalled for 4 weeks at 2.5mg and I refuse to panic this time, which sounds obvious until you try to state the evidence for it. Pulling the figures out of the title: 4…
how much of what we believe about cagrilintide actually comes from CagriSema threads. If this has been answered properly somewhere, link me and I will delete. The…
Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.
Certified reference materials for peptide identity and purity work.
sigmaaldrich.comSeveral compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.
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