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c/orforglipron·posted 3 months ago by u/first_hundred

week 66 check-in — 26kg down, fatigue manageable, one thing confusing me

Speculation Cold Box ×4

week 66 check-in — 26kg down, fatigue manageable, one thing confusing me. Full detail below, and I have tried to keep the editorialising out of it.

Pulling the figures out of the title: week 66 and 26kg. All of it is written down as it happened rather than reconstructed.

Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.

Spent an evening reading about small-molecule agonism at a peptide receptor. Genuinely interesting engineering.

Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.

3,242 up / 2,380 down58% upvoted29 commentsid xe0a9b1 Apr 2026

29 comments

13 in this archive, depth 5

best — the order this archive was captured in

u/dario_boateng71 points·3 months ago

Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all different.

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u/trialwatch_theoMOD36 points·3 months ago

Left up. It is careful about what is peptide and what is not, which is more than most threads here manage.

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u/honest_syringe_maybe27 points·3 months ago

ATTAIN and ACHIEVE are the programmes to keep straight

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u/laila_delgado29 points·3 months ago

Push back: daily dosing is not automatically better adherence. It is a different failure mode, not a solved problem.

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u/anders_karlsen41 points·3 months ago

Yes — nothing containing this is approved anywhere, and the threads keep forgetting it.

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u/incretin_ivypharmacology-26 points·3 months ago

a non-peptide agonist does not degrade the way a peptide does

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u/batch_number_bertievetting1 point·3 months ago·edited

a non-peptide agonist does not degrade the way a peptide does

Adding the standing caveat — unapproved, and research material is not for human use.

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[deleted]15 points·3 months ago

[deleted]

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u/batch_number_bertievetting14 points·3 months ago

small molecule, not a peptide, and that changes everything about it

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u/mateusz_mensah24 points·3 months ago·edited

Yes — nothing containing this is approved anywhere, and the threads keep forgetting it.

Agreed, and it is why the oral peptide comparison keeps misleading people.

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u/fasting_insulin_f11 points·3 months ago

Agreed, and it is why the oral peptide comparison keeps misleading people.

mateusz_mensah is right that milligram comparisons across classes tell you nothing.

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u/ahmed_okafor7 points·3 months ago·edited

mateusz_mensah is right that milligram comparisons across classes tell you nothing.

Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.

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u/dilara_weiss3 points·3 months ago

Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.

This is the fact the whole board hangs on. Small molecule, not peptide.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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