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c/orforglipron·posted 4 months ago by u/rasmus_petrescu

am I the only one who found oral GLP-1 harder than the injections

Speculation Receipts ×9

Slightly embarrassed to be asking this, but: am I the only one who found oral GLP-1 harder than the injections.

The no-timing-restriction thing is the part I would care about most in practice, and it barely gets mentioned here.

Daily rather than weekly sounds trivial until you think about what a missed dose means in each case.

Went looking for independent testing on this and found essentially nothing, which was clarifying.

Would rather be corrected in public than confident in private.

914 up / 155 down85% upvoted30 commentsid xxzhn910 Mar 2026

30 comments

6 in this archive, depth 3

best — the order this archive was captured in

u/viktor_laurent168 points·4 months ago

Milligram comparisons across molecule classes are meaningless. Potency is a property of the molecule at its receptor, not of the number on the label.

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u/erez_yilmaz39 points·4 months ago

Milligram comparisons across molecule classes are meaningless.

Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.

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u/hazard_ratio_halstats27 points·4 months ago

ATTAIN and ACHIEVE are the programmes to keep straight

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u/piotr_bruun101 points·4 months ago

Assumed the peptide purity conversations transferred and they do not. Different analytical problem entirely.

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u/dario_boateng64 points·4 months ago

Are you comparing doses across a small molecule and a peptide?

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u/rasmus_petrescuOP36 points·4 months ago

What analytical method was used — this is not the usual peptide assay question?

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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