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c/sideeffects·posted 2 years ago by u/cormac_danquah

what changed for me between month 8 and month 12

Resolved Clean Column ×5 Well Actually ×1 Sourced ×1

what changed for me between month 8 and month 12, and I want the answer with the reasoning attached rather than just the conclusion.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

13,479 up / 4,997 down73% upvoted43 commentsid o9iwgk1 Apr 2024

43 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/ilias_cabrera1.5k points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 93 probably does not, and that is worth saying to a clinician rather than to us.

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u/cormac_danquahOP661 points·2 years ago

Mine settled at week 27 and has not come back since, across two more steps.

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u/elin_trevino1.1k points·2 years ago

write down when it starts and stops, the pattern is the useful part

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u/quiet_moderatormod0 points·2 years ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/hassan_ostergaard512 points·2 years ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/cormac_danquahOP362 points·2 years ago

How long has it been going on for now?

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u/insulin_syringe_ian245 points·2 years ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/coring_the_stopper-3 points·2 years ago

Nobody warned me about muscle cramps and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/rohan_steiner1 point·2 years ago

What is intake actually looking like — fibre and water especially?

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u/cormac_danquahOP1 point·2 years ago

Is it every week or did it start at a particular dose?

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u/plain_titration_20241 point·2 years ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/amara_haddad195 points·2 years ago

Agreed. Slowing down at meals did more for my sulphur burps than everything I bought to fix it, which was embarrassing to discover.

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u/iman_falk153 points·2 years ago

sulphur burps are unpleasant and they are not dangerous

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u/ipamorelin_i57 points·2 years ago

Yes. Holding the dose is a real option and it does not mean you have failed at anything.

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u/elin_lundgren15 points·2 years ago

fibre and water before you buy anything to fix it

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u/sofia_wikstrom4 points·2 years ago

a rough fortnight at each step is normal, a rough three months is not

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u/ferran_krastev3 points·2 years ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/reta_and_regret14 points·2 years ago

if it is severe or persistent that is a clinician question, not a board question

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u/quiet_moderatorMOD154 points·2 years ago

Removed the specific recommendation. Describe your own experience here; do not tell another member what to take or what dose to be on.

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u/tl_dr_tina97 points·2 years ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/chidi_demir65 points·2 years ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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u/saskia_lokken94 points·2 years ago

holding a dose an extra month is a legitimate answer to bad tolerance

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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