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c/sideeffects·posted 2 years ago by u/chidi_abubakar

someone explain nausea to me like I have not read a paper in years

Side Effects Well Actually ×8 Slow Clap ×3 Cold Box ×1

Trying to get a straight answer on this: someone explain nausea to me like I have not read a paper in years.

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly muscle cramps arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

Held the dose for an extra six weeks instead of stepping. The food noise settled and I lost the same amount anyway.

Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.

8,363 up / 308 down96% upvoted42 commentsid 1jwj217 Nov 2023

42 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/bastian_eriksen1.7k points·2 years ago·edited

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/elin_trevino1.1k points·2 years ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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u/naomi_erdogan581 points·2 years ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/chidi_abubakarOP-9 points·2 years ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/marit_coelho885 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 80 probably does not, and that is worth saying to a clinician rather than to us.

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u/adaeze_brandt540 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/sofia_wikstrom737 points·2 years ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/tl_dr_tina527 points·2 years ago

What is intake actually looking like — fibre and water especially?

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u/iman_castellanos852 points·2 years ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/chidi_abubakar300 points·2 years ago

write down when it starts and stops, the pattern is the useful part

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u/tomas_broberg564 points·2 years ago

Agreed. Slowing down at meals did more for my reflux than everything I bought to fix it, which was embarrassing to discover.

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u/chidi_abubakarOP271 points·2 years ago·edited

Correcting my own comment above: I said day three and my log says day two. Same pattern, wrong day.

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u/halima_mbeki201 points·2 years ago

injection-site soreness for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/rania_marchand92 points·2 years ago·edited

injection-site soreness for the first eight days after each step, then nothing, every single time.

halima_mbeki is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/chidi_abubakarOP448 points·2 years ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/ayesha_erdogan228 points·2 years ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/signe_villalobos209 points·2 years ago

hair shedding follows the weight loss, not the drug, and it stops

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u/karma_irrelevant124 points·2 years ago

the first fortnight after a step is the worst of it, then it settles

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u/constipation_clubside effects146 points·2 years ago

Nobody warned me about injection-site soreness and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/nausea_notesMOD293 points·2 years ago

Removed the specific recommendation. Describe your own experience here; do not tell another member what to take or what dose to be on.

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u/plain_titration_2024281 points·2 years ago

the injection-site soreness that arrives at week 63 out of nowhere is usually something else

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u/zeynep_zielinski145 points·2 years ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/vendorinvestigate_vic121 points·2 years ago

sulphur burps are unpleasant and they are not dangerous

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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