SURPASS

the nausea profile at 7.5 was worse than 10 for me and i cannot explain it. It is the sort of thing everyone half-believes and nobody writes down. Appetite effect for…

endpoint — what am I missing here. I would rather ask a basic question now than get this wrong quietly for two months. Spent an evening with the appendix tables and…

how do you actually verify SURPASS. I would rather ask a basic question now than get this wrong quietly for two months. A confidence interval is the range of effects…

TRIUMPH is doing more work than we give it credit for. Making the case below, and I expect to lose some of it in the comments. Argued for a week about a result and then…

someone explain FLOW to me like I have not read a paper in years. Searched first, found three threads that contradict each other, hence the post. The discontinuation…

Something I keep coming back to: dual agonist — my 18-week log, condensed into one table. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.…

Housekeeping: proposal — a flair for 15mg posts. 15mg — those are the numbers, and they are the ones I am willing to defend. The distribution matters more than the…

the STEP question that gets asked weekly, answered properly. Not a hot take, just something I have not seen said plainly here. Spent an evening with the appendix tables…

can we stop arguing about Zepbound until somebody posts a number. I am not trying to be the "source?" guy. I would just like a source. Sulphur burps for the first eight…

Reporting in. 63 weeks on 5mg, full numbers, ask me anything boring. 63 weeks and 5mg — those are the numbers, and they are the ones I am willing to defend. Came off…

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about endpoint actually comes from SURMOUNT threads. Compared myself to…

The title is the argument: 12 weeks per step is not too slow, it is just unfashionable. Here is the rest of it. Pulling the figures out of the title: 12 weeks. All of…

The title is the whole question — does SELECT actually matter or is it forum lore at this point — but here is why I am asking. Went looking for the registered protocol…

SURPASS — 6 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Spent an evening with the appendix tables…

stalled for 18 weeks at 12.5mg and I refuse to panic this time — a position I have arrived at slowly and would like tested. To save the first four comments: 18 weeks…

Asking properly rather than in a comment on somebody else’s thread: why is nobody talking about the SURPASS-CVOT readout. Vials and pens carry the same molecule; what…

Question in the title, detail here: does the vial concentration change how much dead space costs me. The distribution matters more than the mean. In the trial…

how much of what we believe about endpoint actually comes from SURMOUNT threads. I am not trying to be the "source?" guy. I would just like a source. How to read one of…

how much of what we believe about endpoint actually comes from STEP threads. I would rather ask a basic question now than get this wrong quietly for two months. Spent…

Thinking out loud about this: we are measuring Zepbound at the wrong time and calling it noise. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole…

genuine question about tirzepatide that I am slightly embarrassed to ask. If this has been answered properly somewhere, link me and I will delete. Research-use-only…

The claim in the title is exactly the claim I am making: is 99.3% actually fine or am I being sold a rounding error. Nothing implied beyond it. Pulling the figures out…

Result first, context after: 4th independent test on JEEP — 97.3% on a claimed 97.0%, and the trend is the interesting part . Everything below is how it was ordered,…

unpopular opinion: most of what gets said here about GIP is guesswork. Making the case below, and I expect to lose some of it in the comments. SURMOUNT-1 ran 72 weeks…

Putting this to the board: the FLOW rule is doing its job and people should stop complaining. Why comparing across trials almost never works, with the specific failure…