[Meta] proposal — a flair for 15mg posts
Housekeeping: proposal — a flair for 15mg posts.
15mg — those are the numbers, and they are the ones I am willing to defend.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
Correction to my own post above — I said 5mg and I have been on 7.5mg since the spring. Same argument, wrong number.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
sulphur burps are the signature complaint and they are not dangerous
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your nausea pattern is a guess.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
Push back: "gentler than sema" is a population statement.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Does fatigue follow the day after the shot, or is it spread across the week?
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Week 13 was the first time the scale moved after a five-week stall. I changed nothing in that window.
week 2 is early to draw any conclusion at all
- 1Push back: "gentler than sema" is a population statement. Plenty of people…12 comments in this branch · started by u/laila_wikstrom
- 2It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part…7 comments in this branch · started by u/titration_marshal