help me understand 15mg, I have read the wiki twice
help me understand 15mg, I have read the wiki twice. I would rather ask a basic question now than get this wrong quietly for two months.
15mg. Those are measured, not estimated, and not rounded up in my favour.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.
best — the order this archive was captured in
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
the appetite effect is blunter than sema, in a good way, most weeks
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run.
hassan_nilsen is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
sulphur burps are the signature complaint and they are not dangerous
if 7.5 is working, 10 is not automatically better
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
16kg over 82 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the loud threads are all 15mg.
This matches mine. Milder food noise than I expected, and what there was settled inside a fortnight of each step.
switching from sema is not a dose conversion, there is no clean equivalence
a lot of people plateau nicely at 10mg and never need 15
Week 72 was the first time the scale moved after a five-week stall. I changed nothing in that window.
Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.
hold the dose that works, the ladder is not a leaderboard
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
pens and vials are the same molecule, the price is the difference
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
- 1Went 10 to 12.5 on the calendar and had the worst fortnight of the whole…6 comments in this branch · started by u/hassan_nilsen
- 2Week 72 was the first time the scale moved after a five-week stall. I…6 comments in this branch · started by u/elin_ferrari