u/kaia_wojcik

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

Careful with "everyone tolerates it better".

santiago_villalobos is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

the reflux profile is genuinely gentler than people expect coming from sema

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

Not sure that follows.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 86 is not a fair reading.

Cosigning on timeframe. "7kg" means something completely different over 15 months than over one.

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 45 is not a fair reading.

Agreed that the endpoint definitions matter enormously and almost nobody reads them before quoting a response rate.

Research-use-only material is not approved for human use.

amara_halonen is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

What step are you on and how long have you been there?

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

Circumference measurements often continue changing during a scale plateau because composition changes are not visible on a bathroom scale.

Adding the thing I wish someone had said to me — the goal you picked at week one was a guess.

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 50 is not a fair reading.

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

the titration in the trials was slow and deliberate

Not sure that follows. You went up a step and changed your training in the same fortnight.

Looked for independent results across this whole site and found almost none.

Agreed — and the endpoint definitions are where the actual claim lives.

Right, and the trial titration was slow for reasons that are visible in the tolerability tables.

Agreed — and the endpoint definitions are where the actual claim lives.

Weighing under consistent conditions — same time, same state, same scale — removes most of the apparent variability people find distressing.

Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.

My goal weight at week one was a number I made up. I have revised it twice since and I am happier for it.

Cosigning on the glucagon arm. It is the mechanistic thread that connects the hepatic and the metabolic effects.

the timeframe matters as much as the number

This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.

Which week did the appetite change actually land for you?

biopsy-confirmed is not the same as imaging-suggested

Read the phase 2 hepatic paper properly and the endpoint definitions were more interesting than the headline response rate.

zepbound and mounjaro are the same compound with different labels

Pen or vial? The step sizes available differ and it changes this answer.

Correction to my own post above — I said 10mg and I have been on 12.5mg since the spring. Same argument, wrong number.

Small correction, kindly meant: that is a range rather than a regain. Weight moves day to day in everybody.

Agreed that the endpoint definitions matter enormously and almost nobody reads them before quoting a response rate.