my resting HR went from 58 to 66 on titration and settled back
my resting HR went from 58 to 66 on titration and settled back. Not a hot take, just something I have not seen said plainly here.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
the appetite effect is blunter than sema, in a good way, most weeks
Week 65 was the first time the scale moved after a five-week stall. I changed nothing in that window.
Correction to my own post above — I said 10mg and I have been on 15mg since the spring. Same argument, wrong number.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
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a lot of people plateau nicely at 10mg and never need 15
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
The step schedule question, answered properly, because it comes up weekly.
The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.
What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
2.5mg is a four-week starting dose, not a maintenance dose.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
2.5mg is a four-week starting dose, not a maintenance dose.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
- 1Weekly dosing again, half-life in the same neighbourhood as sema, so a step…6 comments in this branch · started by u/yusuf_ramos