[Meta] proposal — a flair for 15mg posts
Housekeeping: proposal — a flair for 15mg posts. 15mg — those are the numbers, and they are the ones I am willing to defend. The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm. Held 7.5…
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
sulphur burps are the signature complaint and they are not dangerous
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your nausea pattern is a guess.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
Push back: "gentler than sema" is a population statement.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Does fatigue follow the day after the shot, or is it spread across the week?