the nausea profile at 7.5 was worse than 10 for me and i cannot explain it
the nausea profile at 7.5 was worse than 10 for me and i cannot explain it. It is the sort of thing everyone half-believes and nobody writes down.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Week 81 was the first time the scale moved after a five-week stall. I changed nothing in that window.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
sulphur burps are the signature complaint and they are not dangerous
sulphur burps are the signature complaint and they are not dangerous
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
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switching from sema is not a dose conversion, there is no clean equivalence
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
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