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c/tirzepatide·submitted 13 days ago by u/hana_pereira

the nausea profile at 7.5 was worse than 10 for me and i cannot explain it

Trial Databranch of 6 comments

the nausea profile at 7.5 was worse than 10 for me and i cannot explain it. It is the sort of thing everyone half-believes and nobody writes down. Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule. Week 81 was the first time the scale moved after a five-week…

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6 comments, started 12 days ago
u/quiet_moderatorMOD306 points·12 days ago

This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.

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u/fatima_wojcik131 points·12 days ago

sulphur burps are the signature complaint and they are not dangerous

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u/emil_wojcik177 points·12 days ago

sulphur burps are the signature complaint and they are not dangerous

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

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[deleted]59 points·12 days ago

[deleted]

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u/ewan_marchand46 points·11 days ago

switching from sema is not a dose conversion, there is no clean equivalence

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u/fatima_wojcik39 points·12 days ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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