SURPASS

The title is the argument: reading SURMOUNT threads from 2024 and half of it aged badly. Here is the rest of it. Discontinuation rates are a tolerability result. A…

the SURMOUNT rule is doing its job and people should stop complaining. Nothing about this affects the ranking maths, before anyone asks. Switching from semaglutide,…

the SURPASS rule is doing its job and people should stop complaining, and here is what changes in practice if it goes ahead. SURMOUNT-1 ran 72 weeks with the top arm…

someone explain 15mg to me like I have not read a paper in years — that is what I am asking, and I have already read the wiki twice. Hard numbers: 15mg. Anything softer…

SURPASS — 11 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. A confidence interval is the range of…

The title is the argument: SURPASS — 15 things I got wrong before I got it right. Here is the rest of it. Discontinuation rates are a tolerability result. A trial with…

reading SURMOUNT threads from 2024 and half of it aged badly. Making the case below, and I expect to lose some of it in the comments. Quoted a figure here confidently,…

SURMOUNT: what the trials say vs what this community says. Change my mind, genuinely — I have no stake in being right about this. Research-use-only material is not…

Slightly embarrassed to be asking this, but: why does nobody talk about SURPASS. Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed…

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about endpoint actually comes from hazard ratio threads. Why comparing…

SURMOUNT — what am I missing here. If this has been answered properly somewhere, link me and I will delete. Research-use-only material is not approved for human use.…

Short version of the title, which is already short: ERP vs SGN on the same compound, same month — both cleared 98.0%. Longer version underneath. Pulling the figures out…

Thinking out loud about this: the endpoint advice in here is 3 years out of date. 3 years — those are the numbers, and they are the ones I am willing to defend.…

anyone else notice tirzepatide kicking in around week 13, logged the same way every week so the comparison is at least internally fair. The four-week interval in the…

proposal — a flair for Mounjaro posts — posting the reasoning in public because a policy you cannot inspect is just a preference. On comparing yourself with the trial…

Asking properly rather than in a comment on somebody else’s thread: Mounjaro — what am I missing here. On comparing yourself with the trial number. SURMOUNT-1 reported…

hazard ratio is the most under-discussed thing on this board — a position I have arrived at slowly and would like tested. Relative risk reduction without the baseline…

week 36 check-in — 6kg down, sulphur burps manageable, one thing confusing me, and the part I actually want to talk about is at the bottom. Since the title puts numbers…

how much of what we believe about endpoint actually comes from TRIUMPH threads. I would rather ask a basic question now than get this wrong quietly for two months.…

Trying to get a straight answer on this: genuine question about TRIUMPH that I am slightly embarrassed to ask. Why comparing across trials almost never works, with the…

45 weeks, 14kg, and tirzepatide was the hard part, logged the same way every week so the comparison is at least internally fair. The numbers the title promised, since a…

reading 15mg threads from 2024 and half of it aged badly. It is the sort of thing everyone half-believes and nobody writes down. Hard numbers: 15mg. Anything softer…

Zepbound — my 8-week log, condensed into one table. I have gone back and forth on this for months. Sulphur burps for the first eight days after each step, then nothing.…

my ApoB moved and I cannot work out whether SURPASS is why. Change my mind, genuinely — I have no stake in being right about this. Switching from semaglutide, since…

help me understand SURMOUNT, I have read the wiki twice. If this has been answered properly somewhere, link me and I will delete. Switching from semaglutide, since…