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c/tirzepatide·posted 1 year ago by u/tarek_kirchner

[Vendor] ERP vs SGN on the same compound, same month — both cleared 98.0%

Results Receipts ×9 Cold Box ×1 Sourced ×2

Short version of the title, which is already short: ERP vs SGN on the same compound, same month — both cleared 98.0%. Longer version underneath.

Pulling the figures out of the title: 98.0%. All of it is written down as it happened rather than reconstructed.

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

4,289 up / 814 down84% upvoted16 commentsid suxu9323 Mar 2025
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16 comments

10 in this archive, depth 4

best — the order this archive was captured in

u/copay_card_cc330 points·1 year ago·edited

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

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u/neha_falk106 points·1 year ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/ahmed_iyer88 points·1 year ago

hold the dose that works, the ladder is not a leaderboard

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u/marta_dziedzic-37 points·1 year ago

week 9 is early to draw any conclusion at all

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u/emil_wojcik84 points·1 year ago

The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 22 is not a fair reading.

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u/samir_falk92 points·1 year ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/tarek_kirchnerOP56 points·1 year ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/certified_referenceQC20 points·1 year ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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u/nordic_pricing0 points·1 year ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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u/titration_marshalMOD1 point·1 year ago

This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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