why does nobody talk about SURPASS
Slightly embarrassed to be asking this, but: why does nobody talk about SURPASS.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
38kg over 96 weeks, never went past 10mg, and constipation stayed mild the whole way. Posting because the loud threads are all 15mg.
If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.
best — the order this archive was captured in
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
the appetite effect is blunter than sema, in a good way, most weeks
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Did you come to this from sema, and if so how long was the gap?
What step are you on and how long have you been there?
What step are you on and how long have you been there?
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Have you held a step for longer than the four-week minimum at any point?
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
switching from sema is not a dose conversion, there is no clean equivalence
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Week 16 was the first time the scale moved after a five-week stall. I changed nothing in that window.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
- 1The distribution matters more than the mean. In the trial population the…9 comments in this branch · started by u/graph_it_gary
- 2Yes. I stepped to 12.5 because the calendar said so, not because anything…6 comments in this branch · started by u/fatima_wojcik