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c/tirzepatide·submitted 1 months ago by u/cato_girard

why does nobody talk about SURPASS

Trial Databranch of 6 comments

Slightly embarrassed to be asking this, but: why does nobody talk about SURPASS. Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and…

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6 comments, started 1 months ago
u/fatima_wojcik-16 points·1 months ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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u/cato_girardOP1 point·1 months ago

Have you held a step for longer than the four-week minimum at any point?

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u/cato_girardOP1 point·1 months ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

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u/emil_okwuosa1 point·1 months ago

Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.

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u/search_before_post1 point·1 months ago

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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u/graph_it_gary1 point·1 months ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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