anyone else notice tirzepatide kicking in around week 13
anyone else notice tirzepatide kicking in around week 13, logged the same way every week so the comparison is at least internally fair.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
This matches mine. Milder constipation than I expected, and what there was settled inside a fortnight of each step.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Saving this one. It is the clearest statement of the stall problem I have read here.
Week 6 was the first time the scale moved after a five-week stall. I changed nothing in that window.
the appetite effect is blunter than sema, in a good way, most weeks
if 7.5 is working, 10 is not automatically better
zepbound and mounjaro are the same compound with different labels
the four-week step schedule is the label, not folklore
- 1SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.…10 comments in this branch · started by u/georgi_chowdhury
- 2Weekly dosing again, half-life in the same neighbourhood as sema, so a step…6 comments in this branch · started by u/tarek_kirchner