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c/tirzepatide·submitted 1 months ago by u/kaia_cabrera

anyone else notice tirzepatide kicking in around week 13

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anyone else notice tirzepatide kicking in around week 13, logged the same way every week so the comparison is at least internally fair. The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to. It is…

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6 comments, started 1 months ago
u/tarek_kirchner249 points·1 months ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/marit_sandvik190 points·1 months ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/signe_villalobos77 points·1 months ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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u/marit_sandvik-26 points·1 months ago

This matches mine. Milder constipation than I expected, and what there was settled inside a fortnight of each step.

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u/kaia_cabrera22 points·1 months ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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[removed]16 points·1 months ago

[removed by moderator]

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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