stalled for 18 weeks at 12.5mg and I refuse to panic this time
stalled for 18 weeks at 12.5mg and I refuse to panic this time — a position I have arrived at slowly and would like tested.
To save the first four comments: 18 weeks and 12.5mg.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.
best — the order this archive was captured in
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Correction to my own post above — I said 2.5mg and I have been on 15mg since the spring. Same argument, wrong number.
14kg over 53 weeks, never went past 10mg, and reflux stayed mild the whole way. Posting because the loud threads are all 15mg.
What step are you on and how long have you been there?
zepbound and mounjaro are the same compound with different labels
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
The step schedule question, answered properly, because it comes up weekly.
The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.
What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.
2.5 is the starter dose and it is not meant to be the dose that works
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Sulphur burps for the first eight days after each step, then nothing.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
if 7.5 is working, 10 is not automatically better
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
switching from sema is not a dose conversion, there is no clean equivalence
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
pens and vials are the same molecule, the price is the difference
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
- 1if 7.5 is working, 10 is not automatically better7 comments in this branch · started by u/kaia_cabrera
- 2The distribution matters more than the mean. In the trial population the…6 comments in this branch · started by u/piotr_nascimento