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c/tirzepatide·submitted 1 year ago by u/slow_logbook_ftw

stalled for 18 weeks at 12.5mg and I refuse to panic this time

Labbranch of 7 comments

stalled for 18 weeks at 12.5mg and I refuse to panic this time — a position I have arrived at slowly and would like tested. To save the first four comments: 18 weeks and 12.5mg. Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule. The thing nobody warned me about…

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7 comments, started 1 year ago
u/kaia_cabrera84 points·1 year ago

if 7.5 is working, 10 is not automatically better

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u/slow_logbook_ftwOP39 points·1 year ago·edited

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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u/customs_seizure_sid15 points·1 year ago

switching from sema is not a dose conversion, there is no clean equivalence

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u/forest_plot_fionastats10 points·1 year ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/kaia_cabrera5 points·1 year ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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u/mikkel_kimani5 points·1 year ago

pens and vials are the same molecule, the price is the difference

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u/dexa_twice_yearlyMOD49 points·1 year ago

Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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