[Discussion] we are measuring Zepbound at the wrong time and calling it noise
Thinking out loud about this: we are measuring Zepbound at the wrong time and calling it noise.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.
best — the order this archive was captured in
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
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Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
hold the dose that works, the ladder is not a leaderboard
stepping every four weeks is a ceiling on speed, not a schedule you must hit
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 7 is not a fair reading.
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
sulphur burps are the signature complaint and they are not dangerous
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Correction to my own post above — I said 15mg and I have been on 7.5mg since the spring. Same argument, wrong number.
This matches mine. Milder fatigue than I expected, and what there was settled inside a fortnight of each step.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
the appetite effect is blunter than sema, in a good way, most weeks
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
the four-week step schedule is the label, not folklore
Push back: "gentler than sema" is a population statement.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Have you held a step for longer than the four-week minimum at any point?
zepbound and mounjaro are the same compound with different labels
week 4 is early to draw any conclusion at all
week 4 is early to draw any conclusion at all
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
- 1Right. And the sema-to-tirz "conversion" people post is invented. There is…13 comments in this branch · started by u/yusuf_ramos