[Discussion] can we stop arguing about Zepbound until somebody posts a number
can we stop arguing about Zepbound until somebody posts a number. I am not trying to be the "source?" guy. I would just like a source.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
19kg over 48 weeks, never went past 10mg, and muscle cramps stayed mild the whole way. Posting because the loud threads are all 15mg.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Happy to answer the boring questions. Those are usually the ones worth asking.
best — the order this archive was captured in
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Are you comparing yourself with the trial mean or with the people who post the most?
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Pen or vial? The step sizes available differ and it changes this answer.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.