dual agonist

the nausea profile at 7.5 was worse than 10 for me and i cannot explain it. It is the sort of thing everyone half-believes and nobody writes down. Appetite effect for…

Something I keep coming back to: dual agonist — my 18-week log, condensed into one table. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change.…

Housekeeping: proposal — a flair for 15mg posts. 15mg — those are the numbers, and they are the ones I am willing to defend. The distribution matters more than the…

can we stop arguing about Zepbound until somebody posts a number. I am not trying to be the "source?" guy. I would just like a source. Sulphur burps for the first eight…

Something I keep coming back to: my ALT moved and I cannot work out whether dual agonist is why. Imaging-derived liver fat fraction is a surrogate. It correlates with…

Reporting in. 63 weeks on 5mg, full numbers, ask me anything boring. 63 weeks and 5mg — those are the numbers, and they are the ones I am willing to defend. Came off…

The title is the argument: 12 weeks per step is not too slow, it is just unfashionable. Here is the rest of it. Pulling the figures out of the title: 12 weeks. All of…

stalled for 18 weeks at 12.5mg and I refuse to panic this time — a position I have arrived at slowly and would like tested. To save the first four comments: 18 weeks…

Something I keep coming back to: glucagon is the most under-discussed thing on this board. Imaging-derived liver fat fraction is a surrogate. It correlates with…

Homopeptide survo — Medutest came back 98.4% against a claimed 98.0%. One vial, one service, one member paying, which is the only kind of result this board should treat…

Asking properly rather than in a comment on somebody else’s thread: why is nobody talking about the SURPASS-CVOT readout. Vials and pens carry the same molecule; what…

Asking properly rather than in a comment on somebody else’s thread: how do you actually verify biopsy. Went slowly because everything published describes a deliberate…

anyone else notice glucagon kicking in around week 47. Full detail below, and I have tried to keep the editorialising out of it. Imaging-derived liver fat fraction is a…

Question in the title, detail here: does the vial concentration change how much dead space costs me. The distribution matters more than the mean. In the trial…

Thinking out loud about this: we are measuring Zepbound at the wrong time and calling it noise. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole…

genuine question about tirzepatide that I am slightly embarrassed to ask. If this has been answered properly somewhere, link me and I will delete. Research-use-only…

The claim in the title is exactly the claim I am making: is 99.3% actually fine or am I being sold a rounding error. Nothing implied beyond it. Pulling the figures out…

Result first, context after: 4th independent test on JEEP — 97.3% on a claimed 97.0%, and the trend is the interesting part . Everything below is how it was ordered,…

unpopular opinion: most of what gets said here about GIP is guesswork. Making the case below, and I expect to lose some of it in the comments. SURMOUNT-1 ran 72 weeks…

Right: SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. Hard…

how do you actually verify Zepbound. I am not trying to be the "source?" guy. I would just like a source. The step schedule question, answered properly, because it…

8th independent test on QST — 98.6% on a claimed 98.5%, and the trend is the interesting part. I will put the method line and the batch identifier up front because that…

the MASH thing finally clicked for me and I want to write it down, which sounds obvious until you try to state the evidence for it. Independent purity results for this…

how do you actually verify MASH. I would rather ask a basic question now than get this wrong quietly for two months. Read the phase 2 hepatic paper properly and the…

Slightly embarrassed to be asking this, but: genuine question about dual agonist that I am slightly embarrassed to ask. Imaging-derived liver fat fraction is a…