SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%
Right: SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%. I paid for this one myself, nobody sent me anything, and the receipts are in the comments.
Hard numbers: 20.9%, 72 weeks and 30%. Anything softer than that is flagged as an impression.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Sceptical readings welcome. The confident ones are the ones I distrust.
best — the order this archive was captured in
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
week 10 is early to draw any conclusion at all
2.5 is the starter dose and it is not meant to be the dose that works
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Sorting this by controversial is genuinely worth it today. The best answer in here is not the top one.
sulphur burps are the signature complaint and they are not dangerous
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
Correction to my own post above — I said 5mg and I have been on 7.5mg since the spring. Same argument, wrong number.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Which week did the appetite change actually land for you?
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
The step schedule question, answered properly, because it comes up weekly.
The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.
What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
Are you comparing yourself with the trial mean or with the people who post the most?
the appetite effect is blunter than sema, in a good way, most weeks
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
- 1Weekly dosing again, half-life in the same neighbourhood as sema, so a step…7 comments in this branch · started by u/dexa_twice_yearly
- 2The step schedule question, answered properly, because it comes up weekly.…6 comments in this branch · started by u/mod_cold_room