SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%
Right: SURMOUNT-1 was -20.9% at 72 weeks. that is the number, not -30%. I paid for this one myself, nobody sent me anything, and the receipts are in the comments. Hard numbers: 20.9%, 72 weeks and 30%. Anything softer than that is flagged as an impression. On comparing yourself with the trial number. SURMOUNT-1…
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
Correction to my own post above — I said 5mg and I have been on 7.5mg since the spring. Same argument, wrong number.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Which week did the appetite change actually land for you?
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.