dual agonist

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about Mounjaro actually comes from Zepbound threads. On comparing…

small win: MASH stopped being a problem at week 43. Full detail below, and I have tried to keep the editorialising out of it. Imaging-derived liver fat fraction is a…

dual agonist — 21 things I got wrong before I got it right, and I am aware this is a minority view on this board. What this compound is actually being developed for,…

Posting this as a discussion rather than a claim: hepatic fat — 19 things I got wrong before I got it right. Went slowly because everything published describes a…

Filing this under things worth writing down: split one vial across Medutest and Janoshik — 99.3% and 98.7%. To save the first four comments: 99.3% and 98.7%.…

what changed for me between month 5 and month 8. I am not trying to be the "source?" guy. I would just like a source. Assumed the weight numbers were the point and was…

nobody warned me about muscle cramps and I would have liked the warning. Change my mind, genuinely — I have no stake in being right about this. Switching from…

genuine question about MASH that I am slightly embarrassed to ask. I would rather ask a basic question now than get this wrong quietly for two months. Asked here what…

Slightly embarrassed to be asking this, but: how much of what we believe about Mounjaro actually comes from SURMOUNT threads. SURMOUNT-1 ran 72 weeks with the top arm…

Something I keep coming back to: SURPASS is doing more work than we give it credit for. Week 44 was the first time the scale moved after a five-week stall. I changed…

Short version of the title, which is already short: 24th independent test on QSC — 98.4% on a claimed 98.0%, and the trend is the interesting part. Longer version…

biopsy is the most under-discussed thing on this board. I have gone back and forth on this for months. Phase 2 in a biopsy-confirmed population is a demanding design:…

three years of survodutide threads, summarised so you do not have to read them. Not a hot take, just something I have not seen said plainly here. Histological endpoints…

Slightly embarrassed to be asking this, but: why does nobody talk about biopsy. Bought small because the evidence base is early. That is the only defensible position I…

Thinking out loud about this: phase 2 biopsy endpoints, and what "resolution" means. The honest evidence position, written out so this board does not drift. Phase 2…

small win: Mounjaro stopped being a problem at week 66. Posting the boring middle of the process, because the internet is full of the start and the end and nothing…

Reporting in. is it normal to get food noise at week 85. Research-use-only material is not approved for human use. Anything in this thread about how a research vial…

"tirz is stronger than sema" needs a comparator dose or it means nothing. Making the case below, and I expect to lose some of it in the comments. Came off sema and onto…

is it normal to get constipation at week 87, and the part I actually want to talk about is at the bottom. Came off sema and onto tirz with a two-week gap. The first…

stalled for 8 weeks at 1.7mg and I refuse to panic this time. Making the case below, and I expect to lose some of it in the comments. Since the title puts numbers in…

anyone else notice GIP kicking in around week 81, logged the same way every week so the comparison is at least internally fair. Sulphur burps for the first eight days…

Slightly embarrassed to be asking this, but: someone explain biopsy to me like I have not read a paper in years. Bought small because the evidence base is early. That…

hepatic fat is doing more work than we give it credit for. Making the case below, and I expect to lose some of it in the comments. Imaging-derived liver fat fraction is…

is it normal to get constipation at week 7, logged the same way every week so the comparison is at least internally fair. Assumed the weight numbers were the point and…