[Discussion] SURPASS is doing more work than we give it credit for
Something I keep coming back to: SURPASS is doing more work than we give it credit for.
Week 44 was the first time the scale moved after a five-week stall. I changed nothing in that window.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Tell me where this is wrong. That is the useful part of posting it.
best — the order this archive was captured in
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
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hold the dose that works, the ladder is not a leaderboard
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
Which week did the appetite change actually land for you?
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Which week did the appetite change actually land for you?
Saving this one. It is the clearest statement of the stall problem I have read here.
Does early fullness follow the day after the shot, or is it spread across the week?