small win: Mounjaro stopped being a problem at week 66
small win: Mounjaro stopped being a problem at week 66. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
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if 7.5 is working, 10 is not automatically better
Does constipation follow the day after the shot, or is it spread across the week?
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your early fullness pattern is a guess.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Are you comparing yourself with the trial mean or with the people who post the most?
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
switching from sema is not a dose conversion, there is no clean equivalence
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
Did you come to this from sema, and if so how long was the gap?
Same experience with the appetite effect being flatter across the week rather than front-loaded.
the appetite effect is blunter than sema, in a good way, most weeks
- 1switching from sema is not a dose conversion, there is no clean equivalence7 comments in this branch · started by u/aksel_kjaer
- 2Trial identifiers corrected in the title. SURMOUNT and SURPASS are different…6 comments in this branch · started by u/incretin_ivy