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c/tirzepatide·submitted 10 months ago by u/search_before_post

small win: Mounjaro stopped being a problem at week 66

Questionbranch of 6 comments

small win: Mounjaro stopped being a problem at week 66. Posting the boring middle of the process, because the internet is full of the start and the end and nothing else. The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have…

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6 comments, started 10 months ago
u/incretin_ivyMOD123 points·10 months ago

Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.

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[removed]59 points·10 months ago

[removed by moderator]

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u/slow_logbook_ftw49 points·10 months ago

if 7.5 is working, 10 is not automatically better

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u/search_before_postOP43 points·10 months ago

Does constipation follow the day after the shot, or is it spread across the week?

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u/quiet_moderatormod13 points·10 months ago

I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your early fullness pattern is a guess.

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u/tarek_kirchner43 points·10 months ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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