how much of what we believe about Mounjaro actually comes from SURMOUNT threads
Slightly embarrassed to be asking this, but: how much of what we believe about Mounjaro actually comes from SURMOUNT threads.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Happy to answer the boring questions. Those are usually the ones worth asking.
best — the order this archive was captured in
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
The distribution matters more than the mean.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
the four-week step schedule is the label, not folklore
Not sure that follows. You went up a step and changed your training in the same fortnight.
Not sure that follows.
piotr_nascimento is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
Trial identifiers corrected in the title.
Saving this one. It is the clearest statement of the stall problem I have read here.
a lot of people plateau nicely at 10mg and never need 15
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
the trials titrated on a calendar, real people titrate on symptoms
Pen or vial? The step sizes available differ and it changes this answer.
the trials titrated on a calendar, real people titrate on symptoms
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
25kg over 79 weeks, never went past 10mg, and sulphur burps stayed mild the whole way. Posting because the loud threads are all 15mg.
25kg over 79 weeks, never went past 10mg, and sulphur burps stayed mild the whole way.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
if 7.5 is working, 10 is not automatically better
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 29 is not a fair reading.
sulphur burps are the signature complaint and they are not dangerous
What is the waist doing? That is usually the number still moving during a scale stall.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your fatigue pattern is a guess.
pens and vials are the same molecule, the price is the difference
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
- 1Trial identifiers corrected in the title. SURMOUNT and SURPASS are different…18 comments in this branch · started by u/titration_marshal