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c/tapering·posted 1 year ago by u/patient_labslip_log

[Discussion] we are measuring regain at the wrong time and calling it noise

Discussion Well Actually ×1 Cold Box ×2 Clean Column ×2

Posting this as a discussion rather than a claim: we are measuring regain at the wrong time and calling it noise.

Preparing to stop, as described by people here who have done it.

Write down where you are first: dose, date, weight, waist, and an honest note about how appetite feels. That page is what makes the following six months interpretable rather than a fog of impressions.

Decide in advance what you are watching for and over what period — appetite in the first month, weight over three, and a specific threshold at which you would want to revisit the decision. Have the conversation with a clinician before rather than after.

None of that is a schedule. It is a way of arriving at whatever happens next with information rather than with a vague sense of how it is going.

What the evidence says about stopping, written plainly because the framing does real damage.

Withdrawal studies across this class consistently show substantial regain after discontinuation. Appetite typically returns first, well before weight changes. This is a finding about the pharmacology of a chronic condition, in the same way that blood pressure rises again when an antihypertensive is stopped.

People on this board quit in shame over an entirely predictable result, and then avoid coming back because they have interpreted it as a personal failure. It is not. Knowing that in advance is the single most useful thing this board can offer anybody planning to stop.

The habits are what carried it for a while. When they slipped, everything else followed, in that order.

Would rather be corrected in public than confident in private.

11,121 up / 8,174 down58% upvoted36 commentsid et5wfn23 Sep 2024

36 comments

30 in this archive, depth 4

best — the order this archive was captured in

u/dario_stanescu486 points·1 year ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/elin_varga320 points·1 year ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/ismael_varga182 points·1 year ago

Same. A quiet fortnight after stopping tells you very little; the interesting part starts later.

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u/quarter_dose_queenlow and slow89 points·1 year ago

How long were you at the dose you are coming off?

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u/ilias_nakamura0 points·1 year ago

That is a pause rather than a stop, and the plans for the two are not the same.

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u/ferran_krastev-38 points·1 year ago

Is this a pause or a stop? They are different plans.

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u/patient_labslip_logOP1 point·1 year ago

Correcting myself upthread: appetite returned at week 10 for me, not the week I posted.

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u/skip_week_scepticMOD175 points·1 year ago

Removed the taper schedule written for another member. Describe your own experience instead.

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u/neha_mwangi83 points·1 year ago

Removed the taper schedule written for another member.

This is the sentence that reframes the whole board. Appetite first, scale later.

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u/britta_boateng44 points·1 year ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/nikhil_lindqvist44 points·1 year ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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[deleted]16 points·1 year ago

[deleted]

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u/marisol_kravchenko87 points·1 year ago·edited

Removed the taper schedule written for another member.

Adding the one process step — write down where you are before you change anything.

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u/patient_labslip_logOP32 points·1 year ago

Wrote down where I was before changing anything. That single page made the following six months interpretable.

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u/fabio_lehtinen11 points·1 year ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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u/patient_labslip_logOP67 points·1 year ago

write down where you are before you change anything

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u/valeria_girard88 points·1 year ago

Went back on after eight months away. Nobody here made me feel bad about it, which mattered more than I expected.

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u/micro_bump_mick28 points·1 year ago

appetite comes back before the weight does

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u/zeynep_weiss85 points·1 year ago

Agreed. Appetite is the leading indicator and the scale is the lagging one. Watch the first, not the second.

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u/rafael_sjoberg24 points·1 year ago

Right, and the habits from the losing phase are the part that has to outlive the dose.

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u/ilias_kaufmann7 points·1 year ago

coming back later is allowed and it is common

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u/ismael_eriksen24 points·1 year ago

Yes — the withdrawal literature is consistent and it is a pharmacological finding, not a moral one.

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u/andres_restrepo56 points·1 year ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

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u/vial_math_verasyringe math24 points·1 year ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

Agreed — and the exposure lag means the first fortnight tells you almost nothing.

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u/lift_heavy_thingsresistance training13 points·1 year ago

Agreed — and the exposure lag means the first fortnight tells you almost nothing.

vial_math_vera is right that regain is a documented outcome rather than a character verdict.

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u/naomi_ekstrom8 points·1 year ago

What is prompting the decision — cost, supply, side effects, or something else?

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u/taper_off_tabitha20 points·1 year ago

Stretched from seven days to ten to twelve over four months. Appetite told me where the limit was each time.

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u/zeynep_ndiaye8 points·1 year ago

interval stretching is the most commonly described approach here

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u/rekha_teixeira36 points·1 year ago

nobody here can write you a taper schedule

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u/lane_watchermod · logistics30 points·1 year ago

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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