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u/quarter_dose_queen

Microdosing evangelist. 0.125 increments changed my life and my nausea.

long-standing contributor · low and slow · joined 22 Jan 2024

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59comments

comment on [PSA] your bac water is fine, your fridge door is not in c/reconstitution · 2 points · 21 hr ago

I would not round that figure. At 5mg/mL a rounding error of two units is a real fraction of the intended amount.

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comment on wait so is 0.25 the "real" dose or is that just the starter in c/newbiequestions · 41 points · 2 days ago

you're not. give it the full four weeks before you even start asking that question.

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comment on week two, nothing is happening, everyone says that is normal, is it in c/newbiequestions · 121 points · 2 days ago

i felt nothing until week five and then it arrived all at once. plenty of people describe exactly that.

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comment on [Log] six months of 0.125mg bumps, the full boring spreadsheet in c/dosinglogs · 51 points · 2 days ago

that's genuinely lovely to hear, keep the log going, this granularity is rare and useful

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comment on wait so is 0.25 the "real" dose or is that just the starter in c/newbiequestions · 122 points · 2 days ago

the ladder exists because jumping straight to a "real" dose is how you end up in the bathroom for three days. slow is the whole point, not a delay before the point.

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comment on [Discussion] why did splitting/microdosing culture even take off here given the total lack of trial data in c/glp1science · 121 points · 3 days ago

speaking as someone who's very publicly pro-microdosing: I think part of it is also that the standard step sizes genuinely are rough for a meaningful chunk of people, and splitting/microdosing is the only lever available without a formal smaller-increment product existing. People reach for what's available.

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comment on two weeks in, scale hasn’t moved, is that actually normal in c/semaglutide · 44 points · 3 days ago

if it makes you feel better I felt nothing for the first three weeks and I'm now 14 months in and fine

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comment on [Log] six months of 0.125mg bumps, the full boring spreadsheet in c/dosinglogs · 178 points · 3 days ago

this is basically my whole account's reason for existing. 0.125 increments changed my nausea situation completely compared to the standard steps. following this log closely. edit: meant 0.125 increments, originally typo'd 0.25 which would defeat the entire point.

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comment on [Explainer] why 1mL syringes cause overdoses and 0.3mL ones do not in c/reconstitution · 10 points · 3 days ago

Disagreeing with this line only: adding more water is not a safety margin, it is a different divisor.

piotr_bruun has the units point exactly right. They are a volume on the barrel and nothing else.

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comment on two weeks in, scale hasn’t moved, is that actually normal in c/semaglutide · 176 points · 3 days ago

completely normal. 0.25 is a priming dose for a huge chunk of people, not a weight-loss dose. two weeks of nothing is the most common report on this exact question.

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comment on [Regret] went 0.25 → 1.0 in three weeks and learned why that is dumb in c/darkspot · 234 points · 3 days ago

And the mirror of this: I went 0.125 increments and took nine months to reach a dose other people reached in five. Same place, less vomiting, and I never had a week I could not work.

The people who go slowly do not post as much because "nothing dramatic happened" is not a thread.

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comment on [Trial Data] what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed in c/tapering · 11 points · 6 days ago

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

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comment on [Math] someone check my arithmetic before i draw this up in c/reconstitution · 19 points · 9 days ago

Are you accounting for the powder volume, or is that where the confusion is?

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comment on cloudy after reconstitution — discard, right? right. in c/reconstitution · 5 points · 12 days ago

Asked SGN what volume they reconstitute to for their own stability testing and they answered in one line. Useful thing to know.

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comment on [Regain] appetite came back over five weeks, here is the timeline in c/tapering · 11 points · 12 days ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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comment on [Discussion] restarting is not failing and we should say that louder in c/tapering · 1 points · 14 days ago

Preparing to stop, as described by people here who have done it.

Agreed — and the exposure lag means the first fortnight tells you almost nothing.

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comment on reconstituted at 1mL instead of 2mL and caught it before injecting. lucky. in c/reconstitution · 7 points · 17 days ago

Spent 20 weeks confused about this until somebody drew the table for me. 5mg, 3mL, 1.67mg/mL, 1.5mg is 90 units. That is the whole thing.

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comment on reconstituted at 1mL instead of 2mL and caught it before injecting. lucky. in c/reconstitution · 16 points · 17 days ago

Is that a U-100 syringe? The barrel markings change the answer completely.

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comment on [Concluded] 104 weeks. final numbers. thanks for reading. in c/dosinglogs · 44 points · 19 days ago

Wrote the concentration into the log as well as on the vial. Have referred back to it more than once.

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comment on anyone else notice regain kicking in around week 20 in c/tapering · 1 points · 20 days ago

Stopped for cost reasons. Appetite came back at about week 20, well before the scale moved, exactly as this board said it would.

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comment on someone explain units to me like I have not read a paper in years in c/reconstitution · 28 points · 22 days ago

What is written on the vial right now?

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comment on [Question] how do you actually verify concentration in c/reconstitution · 19 points · 25 days ago

How many mg in the vial and how many mL are you adding?

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comment on regret — my 19-week log, condensed into one table in c/darkspot · 40 points · 2 months ago

money lost to a shop with nothing on file is the recurring story

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comment on does bacteriostatic water actually matter or is it forum lore at this point in c/reconstitution · 20 points · 2 months ago

Disagree with the "more water is safer" framing. It is not safer, it is just a different number to divide by.

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comment on why does nobody talk about lost money in c/darkspot · 35 points · 5 months ago

The pattern in the money-loss posts, since there is one.

Almost none of them involve a documented supplier with an independent testing record. They involve an unfamiliar shop, a price that seemed good, a decision made in a hurry, and no small first order.

The procedural fix is the one this site keeps repeating: buy small from anybody new, ask for a batch-specific document before paying, test what arrives, and only then commit. It is boring, it costs a small order, and it would have prevented most of what is written on this board. Where a name has nothing verifiable on file, that is a statement about the evidence available rather than about anyone’s conduct — and keeping that distinction is why these reports stay useful.

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comment on [Discussion] regret is doing more work than we give it credit for in c/darkspot · 81 points · 5 months ago

somebody will read this at the point you were at, and it will help

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comment on mg/mL — 16 things I got wrong before I got it right in c/reconstitution · 0 points · 6 months ago

Aim the stream down the wall of the vial rather than into the cake. Reconstitution is a solubility problem, not a mixing problem, and mechanical shear does nothing helpful.

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comment on tried tracking for 13 weeks. here is what happened. in c/dosinglogs · 35 points · 6 months ago

Why contemporaneous beats reconstructed, with the failure mode.

Memory smooths. Reconstructing a fortnight from recollection produces a series that is more regular, more consistent with your current beliefs, and quietly wrong in a direction that flatters the story you are already telling.

I found this out by reconstructing six weeks and later finding order receipts that contradicted my own entries. The log was not a little wrong; it was wrong in exactly the direction that made my narrative work. Write it down on the day, even the boring days, especially the boring days.

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comment on week 53 check-in — 10kg down, fatigue manageable, one thing confusing me in c/darkspot · 4 points · 6 months ago

A public correction of a wrong accusation is worth more to the record than the original report, because it is the thing that keeps the rest of the archive trustworthy.

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comment on [PSA] stopped is not what most of this community thinks it is in c/darkspot · 25 points · 7 months ago

Not convinced that was avoidable. Some of this is genuinely bad luck and treating everything as a lesson is its own trap.

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comment on the dead space thing finally clicked for me and I want to write it down in c/reconstitution · 54 points · 7 months ago

the number you write down is the number you will trust at 6am

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comment on the dead space thing finally clicked for me and I want to write it down in c/reconstitution · 1 points · 7 months ago

That only works if the fill weight is exactly the label weight, and it usually is not exactly anything.

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comment on 6 months in and weight is still the thing I get wrong in c/dosinglogs · 4 points · 8 months ago

Attribution requires that one thing change at a time.

Agreed — and the payoff genuinely arrives in month six, not week two.

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comment on reading bacteriostatic water threads from 2024 and half of it aged badly in c/reconstitution · 1 points · 9 months ago

Are you accounting for the powder volume, or is that where the confusion is?

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comment on my triglycerides moved and I cannot work out whether weekly update is why in c/dosinglogs · 122 points · 9 months ago

Careful — posting a log as a schedule for other people to follow is not what this board is for.

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comment on [PSA] what went wrong is not what most of this community thinks it is in c/darkspot · -15 points · 9 months ago

This. Correcting a wrong accusation in public is the hardest and most valuable post anybody makes here.

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comment on mg/mL is the most under-discussed thing on this board in c/reconstitution · 26 points · 10 months ago

What is written on the vial right now?

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comment on why does nobody talk about regret in c/darkspot · 33 points · 10 months ago

Did you write anything down at the time?

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comment on why does nobody talk about regret in c/darkspot · 28 points · 10 months ago

Name removed.

burned_once_twice is right that it was procedural. The procedure was not written down anywhere for you to follow.

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