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c/tapering·posted 5 months ago by u/piotr_bruun

someone explain appetite return to me like I have not read a paper in years

Results Cold Box ×7 The Quiet One ×2

Question in the title, detail here: someone explain appetite return to me like I have not read a paper in years.

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

1,643 up / 332 down83% upvoted50 commentsid 1ihuj42 Feb 2026

50 comments

20 in this archive, depth 4

best — the order this archive was captured in

u/taper_off_tabitha-5 points·5 months ago

What the evidence says about stopping, written plainly because the framing does real damage.

Withdrawal studies across this class consistently show substantial regain after discontinuation. Appetite typically returns first, well before weight changes. This is a finding about the pharmacology of a chronic condition, in the same way that blood pressure rises again when an antihypertensive is stopped.

People on this board quit in shame over an entirely predictable result, and then avoid coming back because they have interpreted it as a personal failure. It is not. Knowing that in advance is the single most useful thing this board can offer anybody planning to stop.

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[deleted]1 point·5 months ago

[deleted]

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u/micro_bump_mick1 point·5 months ago

Cosigning that cost and supply are legitimate reasons. Most of the stopping threads here are one of those two.

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u/zeynep_villalobos112 points·5 months ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

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u/ismael_varga67 points·5 months ago

Stopped abruptly once and gradually once. The gradual one was easier to interpret because I could see what was changing.

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u/yara_lindholm56 points·5 months ago

the withdrawal data is unambiguous and it is not about willpower

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u/marta_dziedzic43 points·5 months ago

regain is the expected outcome and framing it as failure helps nobody

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u/taper_off_tabithaMOD31 points·5 months ago

Edited a comment framing regain as a moral failure. The documented outcome is not a character verdict.

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u/marisol_kravchenko19 points·5 months ago

Edited a comment framing regain as a moral failure.

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/piotr_bruunOP12 points·5 months ago

Regained most of it over a year and spent that year assuming it was my fault. It was not; it is what the literature describes.

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u/micro_bump_mick31 points·5 months ago

Why the first fortnight tells you nothing.

With a week-long half-life, exposure declines over several weeks after a final dose rather than ending with it. So the first two weeks after stopping are still a tail of the previous state, and the stability people report in that window is not evidence about the months after it.

The reports here are fairly consistent: appetite noticeably different somewhere in the second month, weight following later, and the trajectory strongly influenced by whether the habits from the losing phase survived. That is not a prediction for anybody in particular, and it is not a schedule — it is the shape of what members describe, which is the most this board can honestly offer.

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u/piotr_bruunOP13 points·5 months ago

Is this a pause or a stop? They are different plans.

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u/dario_vermeulen4 points·5 months ago

nobody here can write you a taper schedule

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u/customs_seizure_sid22 points·5 months ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/marisol_kravchenko18 points·5 months ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/honest_syringe_20250 points·5 months ago

appetite comes back before the weight does

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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