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c/tapering·submitted 5 months ago by u/piotr_bruun

someone explain appetite return to me like I have not read a paper in years

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Question in the title, detail here: someone explain appetite return to me like I have not read a paper in years. Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a…

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6 comments, started 5 months ago
u/customs_seizure_sid22 points·5 months ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/marisol_kravchenko18 points·5 months ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/honest_syringe_20250 points·5 months ago

appetite comes back before the weight does

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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