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c/tapering·posted 2 months ago by u/ignacio_silva

[Discussion] can we stop arguing about regain until somebody posts a number

Discussion Well Actually ×6

can we stop arguing about regain until somebody posts a number. I would rather ask a basic question now than get this wrong quietly for two months.

Stopped abruptly once and gradually once. The gradual one was easier to interpret because I could see what was changing.

The habits are what carried it for a while. When they slipped, everything else followed, in that order.

What the evidence says about stopping, written plainly because the framing does real damage.

Withdrawal studies across this class consistently show substantial regain after discontinuation. Appetite typically returns first, well before weight changes. This is a finding about the pharmacology of a chronic condition, in the same way that blood pressure rises again when an antihypertensive is stopped.

People on this board quit in shame over an entirely predictable result, and then avoid coming back because they have interpreted it as a personal failure. It is not. Knowing that in advance is the single most useful thing this board can offer anybody planning to stop.

That is everything I have. The rest is opinion and I have tried to keep it out.

440 up / 78 down85% upvoted11 commentsid 1fq1no12 May 2026

11 comments

11 in this archive, depth 3

best — the order this archive was captured in

u/marisol_kravchenko17 points·2 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/maintenance_mode_maxmaintenance25 points·2 months ago·edited

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

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u/taper_off_tabitha6 points·2 months ago

Went back on after eight months away. Nobody here made me feel bad about it, which mattered more than I expected.

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u/ferran_krastev8 points·2 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight chang

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/priya_guerrero5 points·2 months ago

Stretched from seven days to ten to twelve over four months. Appetite told me where the limit was each time.

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u/dario_vermeulen3 points·2 months ago

regain is the expected outcome and framing it as failure helps nobody

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u/rina_bergstrom12 points·2 months ago

Yes — have the conversation before rather than after. That is the one piece of process advice this board can give.

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u/yara_lindholm8 points·2 months ago·edited

Stopped for cost reasons. Appetite came back at about week 17, well before the scale moved, exactly as this board said it would.

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u/skip_week_scepticMOD7 points·2 months ago

Removed the taper schedule written for another member. Describe your own experience instead.

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u/nikhil_lindqvist10 points·2 months ago

That is a pause rather than a stop, and the plans for the two are not the same.

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u/chidi_roos11 points·2 months ago·edited

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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