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c/tapering·submitted 2 months ago by u/ignacio_silva

[Discussion] can we stop arguing about regain until somebody posts a number

Discussionbranch of 6 comments

can we stop arguing about regain until somebody posts a number. I would rather ask a basic question now than get this wrong quietly for two months. Stopped abruptly once and gradually once. The gradual one was easier to interpret because I could see what was changing. The habits are what carried it for a while. When…

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6 comments, started 2 months ago
u/marisol_kravchenko17 points·2 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/maintenance_mode_maxmaintenance25 points·2 months ago·edited

Interval stretching lowers the trough concentration while keeping the dose; dose reduction lowers the level while keeping the rhythm. They are different interventions with different subjective profiles.

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u/taper_off_tabitha6 points·2 months ago

Went back on after eight months away. Nobody here made me feel bad about it, which mattered more than I expected.

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u/ferran_krastev8 points·2 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight chang

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/priya_guerrero5 points·2 months ago

Stretched from seven days to ten to twelve over four months. Appetite told me where the limit was each time.

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u/dario_vermeulen3 points·2 months ago

regain is the expected outcome and framing it as failure helps nobody

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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