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c/sideeffects·posted 8 months ago by u/kavya_kravchenko

is it normal to get injection-site soreness at week 44

Question Well Actually ×3 Slow Clap ×1

is it normal to get injection-site soreness at week 44, logged the same way every week so the comparison is at least internally fair.

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly food noise arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

Held the dose for an extra six weeks instead of stepping. The sulphur burps settled and I lost the same amount anyway.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

1,807 up / 336 down84% upvoted65 commentsid fotm2s18 Nov 2025

65 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/graph_it_gary302 points·8 months ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/mikkel_kimani188 points·8 months ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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u/kavya_kravchenkoOP-11 points·8 months ago

Agreed on writing it down.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/kavya_kravchenkoOP0 points·8 months ago

How long has it been going on for now?

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u/bastian_eriksen127 points·8 months ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/kavya_kravchenkoOP68 points·8 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/rekha_mbeki186 points·8 months ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/sena_teixeira61 points·8 months ago

fatigue plus low intake is usually just low intake

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u/quiet_moderatormod39 points·8 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/tomas_broberg14 points·8 months ago

fibre and water before you buy anything to fix it

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u/rania_marchand9 points·8 months ago·edited

fibre and water before you buy anything to fix it

Disagreeing with this one line: that symptom is not on the wait-and-see list and should not be posted as though it is.

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u/sena_teixeira3 points·8 months ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/idris_iyer4 points·8 months ago

the first fortnight after a step is the worst of it, then it settles

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u/zeynep_zielinski106 points·8 months ago

How long after a step up did this start?

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u/placebo_arm_pam88 points·8 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/reta_and_regret55 points·8 months ago

Are you eating in the couple of hours before you sleep?

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u/elin_lundgren22 points·8 months ago

sulphur burps are unpleasant and they are not dangerous

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u/iman_falk50 points·8 months ago·edited

Constipation is mostly reduced intake plus reduced fluid, not a direct effect.

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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u/hassan_castellanos11 points·8 months ago

write down when it starts and stops, the pattern is the useful part

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u/coring_the_stopper84 points·8 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/halima_mbeki46 points·8 months ago

the constipation that arrives at week 12 out of nowhere is usually something else

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u/adnan_karlsen14 points·8 months ago

the food noise going quiet is the effect people came for, and reflux is the toll for the first fortnight

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u/piotr_bruun49 points·8 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss.

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/line_petrov14 points·8 months ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/elin_lindqvist7 points·8 months ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/hassan_ostergaard5 points·8 months ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 10 probably does not, and that is worth saying to a clinician rather than to us.

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u/piotr_bruun81 points·8 months ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/ferran_krastev33 points·8 months ago

Yes. Holding the dose is a real option and it does not mean you have failed at anything.

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u/signe_villalobos102 points·8 months ago

Which day of the week relative to the shot does it hit?

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u/quiet_moderatorMOD63 points·8 months ago

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

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