[Results] 81 weeks, 20kg, and weekly dosing was the hard part
81 weeks, 20kg, and weekly dosing was the hard part, logged the same way every week so the comparison is at least internally fair.
81 weeks and 20kg — those are the numbers, and they are the ones I am willing to defend.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.
I will update this if the picture changes rather than quietly leaving it up.
best — the order this archive was captured in
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
Retitled to match the body. The original promised a comparison the post does not make.
I would push back gently. Going up because the scale paused is the single most common mistake described on this board.
Retitled to match the body.
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
dose day drift of a day either way is fine, the curve barely notices
Strongly agree on protein. It did more for my sulphur burps than any of the things I bought to fix my sulphur burps.
Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Weight change and appetite change are different endpoints on different timescales.
marta_trevino is describing the standard shape here and it matches the trial data better than most anecdotes do.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
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Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.
if 1.0mg is working there is no prize for going up
Yes. Week 91 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
Sat at 0.5mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the constipation.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
Disagree.
Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.
STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the reflux usually fades at a stable dose.
Same injection day each week, or has it drifted?
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
- 1The mental model that finally made this click for me: there are two curves,…8 comments in this branch · started by u/boots_or_bust
- 2STEP-1 ran 68 weeks and landed just under 15% mean body weight change on…8 comments in this branch · started by u/noor_hovland