[Results] 81 weeks, 20kg, and weekly dosing was the hard part
81 weeks, 20kg, and weekly dosing was the hard part, logged the same way every week so the comparison is at least internally fair. 81 weeks and 20kg — those are the numbers, and they are the ones I am willing to defend. The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve…
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
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Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.
if 1.0mg is working there is no prize for going up
Yes. Week 91 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
Sat at 0.5mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the constipation.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.