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c/semaglutide·posted 1 year ago by u/greta_lokken

how much of what we believe about food noise actually comes from 2.4mg threads

PSA Cold Box ×7 Well Actually ×2 Receipts ×1

Trying to get a straight answer on this: how much of what we believe about food noise actually comes from 2.4mg threads.

Figures up front so nobody has to dig: 2.4mg.

The mental model that finally made this click for me: there are two curves, and people watch the wrong one.

The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.

Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.

injection-site soreness made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

10,705 up / 340 down97% upvoted32 commentsid 1el83h15 Feb 2025

32 comments

8 in this archive, depth 2

best — the order this archive was captured in

u/quiet_moderatorMOD588 points·1 year ago

Retitled to match the body. The original promised a comparison the post does not make.

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u/katrin_diallo-35 points·1 year ago

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

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u/helga_vermeulen-51 points·1 year ago

protein first, then everything else gets easier

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u/rasmus_kimani288 points·1 year ago

staying at 1.7mg for an extra month is a legitimate plan

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u/joaquin_stanescu227 points·1 year ago

if 0.25mg is working there is no prize for going up

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[removed]198 points·1 year ago

[removed by moderator]

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u/lane_map_larrylogistics189 points·1 year ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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u/zeynep_zielinski0 points·1 year ago

First month I lost almost nothing and nearly quit.

Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.

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