the Wegovy question that gets asked weekly, answered properly
the Wegovy question that gets asked weekly, answered properly, and I am aware this is a minority view on this board.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the sulphur burps usually fades at a stable dose.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.
best — the order this archive was captured in
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Weight change and appetite change are different endpoints on different timescales.
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
Agreed, and the bit people skip is that the ladder is a tolerance ladder. It is not a potency ranking.
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That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
Same. I sat at 0.5mg for three months because it was working and there was nothing to fix.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.
Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
the food noise going quiet is the effect people actually describe
staying at 2.4mg for an extra month is a legitimate plan
the ladder exists because the gut needs the time, not because the pharmacy likes paperwork
The mental model that finally made this click for me: there are two curves, and people watch the wrong one.
The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.
Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.
STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure
My stall was eleven weeks. Eleven. Then it moved again without me changing anything at all.
do not chase somebody else’s titration schedule, they are not you
This matches me almost exactly, right down to the reflux showing up on the second day and being gone by the fourth.
Did protein intake change in the same window?
How long was the stall before you decided it was a stall?
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
On the "everybody ends up at 2.4" claim, which comes up every few weeks.
The escalation schedule in the trials was designed to get people to a fixed study dose. Real use is not a trial. The dose that keeps your appetite quiet with side effects you can live with is the dose, and for a lot of people on this board that has been 0.5mg for a very long time.
The counter-argument, which is fair: some people genuinely do need the top of the range, and staying low out of caution costs them months. That is a conversation with someone who knows your history, not with us.
- 1My stall was eleven weeks. Eleven. Then it moved again without me changing…6 comments in this branch · started by u/rohan_steiner