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c/semaglutide·submitted 9 months ago by u/careful_gradient_again

[Results] 81 weeks, 20kg, and weekly dosing was the hard part

Resultsbranch of 8 comments

81 weeks, 20kg, and weekly dosing was the hard part, logged the same way every week so the comparison is at least internally fair. 81 weeks and 20kg — those are the numbers, and they are the ones I am willing to defend. The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve…

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8 comments, started 9 months ago
u/boots_or_bust103 points·9 months ago

The mental model that finally made this click for me: there are two curves, and people watch the wrong one.

The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.

Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.

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u/titration_marshalMOD55 points·9 months ago

Retitled to match the body. The original promised a comparison the post does not make.

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u/alcohol_aversion43 points·9 months ago

I would push back gently. Going up because the scale paused is the single most common mistake described on this board.

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u/endpoint_creep68 points·9 months ago

Retitled to match the body.

This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.

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u/careful_gradient_againOP59 points·9 months ago

dose day drift of a day either way is fine, the curve barely notices

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u/nausea_notesside effects22 points·9 months ago

Strongly agree on protein. It did more for my sulphur burps than any of the things I bought to fix my sulphur burps.

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u/arne_restrepo18 points·9 months ago

Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.

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u/stubborn_batchlist_only15 points·9 months ago

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.

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