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c/sideeffects·posted 2 years ago by u/aa_analysis_andy

[Discussion] the nausea advice in here is 3 years out of date

Discussion Clean Column ×7 Slow Clap ×3

the nausea advice in here is 3 years out of date. Making the case below, and I expect to lose some of it in the comments.

Pulling the figures out of the title: 3 years. All of it is written down as it happened rather than reconstructed.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

Would rather be corrected in public than confident in private.

1,908 up / 672 down74% upvoted62 commentsid nfk3dn13 May 2024

62 comments

24 in this archive, depth 5

best — the order this archive was captured in

u/blank_injection163 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 53 probably does not, and that is worth saying to a clinician rather than to us.

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u/fatima_asante112 points·2 years ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/aa_analysis_andyOP73 points·2 years ago

the food noise that arrives at week 3 out of nowhere is usually something else

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u/tomas_broberg66 points·2 years ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/aa_analysis_andyOP30 points·2 years ago

reflux at night, try not eating in the three hours before bed

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u/iman_castellanos53 points·2 years ago·edited

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/hassan_ostergaard28 points·2 years ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/quiet_moderatormod14 points·2 years ago

Are you eating in the couple of hours before you sleep?

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u/step_therapy_s3 points·2 years ago

Which day of the week relative to the shot does it hit?

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u/slow_logbook_ftw4 points·2 years ago·edited

a rough fortnight at each step is normal, a rough three months is not

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u/constipation_clubside effects62 points·2 years ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/enzo_danquah17 points·2 years ago

the food noise going quiet is the effect people came for, and nausea is the toll for the first fortnight

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u/hassan_castellanos13 points·2 years ago

the first fortnight after a step is the worst of it, then it settles

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u/nausea_notesside effects4 points·2 years ago

Held the dose for an extra six weeks instead of stepping. The muscle cramps settled and I lost the same amount anyway.

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u/ahmed_rasmussen0 points·2 years ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/food_noise_gonemaintenance34 points·2 years ago

fatigue plus low intake is usually just low intake

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u/signe_villalobos-27 points·2 years ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/ahmed_rasmussen1 point·2 years ago

Mine settled at week 18 and has not come back since, across two more steps.

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u/aa_analysis_andyOP1 point·2 years ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/thermal_mass_tom37 points·2 years ago

How long has it been going on for now?

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u/sena_teixeira15 points·2 years ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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u/fibre_forward4 points·2 years ago

hair shedding follows the weight loss, not the drug, and it stops

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u/ilias_cabrera6 points·2 years ago

nobody warns you about how much of this is timing rather than dose

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u/coring_the_stopper4 points·2 years ago

What is intake actually looking like — fibre and water especially?

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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