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c/sideeffects·posted 1 year ago by u/rohan_steiner

nobody warned me about food noise and I would have liked the warning

PSA Clean Column ×9 Sourced ×2 Slow Clap ×1

nobody warned me about food noise and I would have liked the warning. I have gone back and forth on this for months.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

6,335 up / 659 down91% upvoted60 commentsid givkno29 Jul 2025

60 comments

29 in this archive, depth 5

best — the order this archive was captured in

u/food_noise_gonemaintenance813 points·12 months ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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u/adaeze_brandt204 points·12 months ago

How long after a step up did this start?

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u/rohan_steinerOP117 points·12 months ago

What is intake actually looking like — fibre and water especially?

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u/enzo_danquah524 points·12 months ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/elin_lindqvist122 points·12 months ago

nobody warns you about how much of this is timing rather than dose

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u/rohan_steinerOP70 points·12 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/rohan_steinerOP37 points·12 months ago·edited

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/chidi_abubakar13 points·12 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/ferran_krastev44 points·12 months ago

write down when it starts and stops, the pattern is the useful part

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u/ferritin_low95 points·12 months ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/elin_lundgren173 points·12 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/halima_mbeki352 points·12 months ago

sulphur burps are unpleasant and they are not dangerous

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u/quiet_moderatormod165 points·12 months ago

if it is severe or persistent that is a clinician question, not a board question

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u/nabila_ogunleye114 points·12 months ago

Agreed. Slowing down at meals did more for my nausea than everything I bought to fix it, which was embarrassing to discover.

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u/food_noise_gonemaintenance92 points·12 months ago

Correcting my own comment above: I said day three and my log says day two. Same pattern, wrong day.

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u/enzo_danquah68 points·12 months ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/ayesha_radich52 points·12 months ago

nausea for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/brigade_detector38 points·12 months ago

smaller meals, earlier, is the boring advice that works

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u/diego_sorensen300 points·1 year ago

eating slower does more than most of the supplements people recommend

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u/sanne_laurent373 points·1 year ago

a rough fortnight at each step is normal, a rough three months is not

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u/slow_logbook_ftw284 points·12 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/gentle_correctionnice about it228 points·12 months ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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[deleted]269 points·12 months ago

[deleted]

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u/ahmed_rasmussen161 points·12 months ago

fibre and water before you buy anything to fix it

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u/karma_irrelevant-29 points·12 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/ipamorelin_i202 points·1 year ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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